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OCR: paradox IIn 1972 L-dopa was first found to cause a suppression of GH in many patients wit dopamine acromegaly; bromocriptine, a long-acting cts are agonist, also has this property. These effe d antagonised by haloperidol, pimozide ar mine metoclopramide which are specific dopa antagonists. The hypothalamic hormone 1 in somatostatin, also decreases GH secretion -life meansacromegaly. Unfortunately, its short hal es. that its effects wear off after a few minut ostatin (e.g.Recently, long-acting analogues of soma e in the octreotide) have become available for us eleasing treatment of acromegaly. Thyrotrophin asing hormone (TRH) and gonadotrophin rel retion in hormone (GnRH) may also cause GH se hirty per many acromegalic patients, twenty and t ects. cent respectively, but not in normal sub